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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e353f86797dde00183edd78e15160f0d6a2cd1790d6d21f0665aea1e75d61146' 
  AND token = 'yq61D+mBw7zYP0fr+ku0yLlFvgP/VRxPl1zB6IW3fpY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}