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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f591e7290e5ecab1208ec6da86b376fe49b3c2ce94deed253242f99b35048f30' 
  AND token = 'fj2t0HczknEL+hLU1OqQiyQ1OCUxKXycwkLPwVLveVs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}