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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '580d02a5802c2caea3e6b295d6baa31b0706f9ef4ce63391b566c8241f27e26c' 
  AND token = 'xEATIwcJjVTjEtDDuPsW1aQN1WlcKRrIH+fk42CFaUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}