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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b65f4343f76caa9ab8be2acc0fc716c40ef655eb6e77ae914097f26469d1d1e' 
  AND token = 'lOusg8sMDQFbmFgEb+FVEM8cfFeM1NJ5PXxIuOCqJk4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}