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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54c41867f43a6f485a3202f0f576998d59b4b139e27b6b0a3f869bcd64c77f2f' 
  AND token = 'mqY/KAAeeMsvDw651F4iWsR3tyOKVVOGbKfpQ5JW2es=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}