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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '29b6e13f94e0ffca3bad79d827d901cb702c29c1146407ab65c33199a32f6d40' 
  AND token = 'nS2o/Mifu9vLpjMVpK/rakHUyTZI7MwbdIHmnyL/uKg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}