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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb9389837f07e30c65db196be2db09577a1ffa02a82c0cdc455a6df458a299e9' 
  AND token = 'SN8UetSiy/y7YgXscVmGJYLcmKoSfjKaMfOX8DcRfYw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}