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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '51dd7eb2dc4d370bc8b94171fb27cc643f343dcb0fa5c90199abee120f51a22b' 
  AND token = 'tUdzFMoLRkcbFVLIi2GCQaMSIm5+C7vmc2lMhI+blNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}