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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21055a7b16d9df3e70d2e2226a2478e7aace0c2022e5ea09800b31378fc7885d' 
  AND token = 'Mlq70kW8QJ0DyZvDP4vNShsf7eQlCFlVt2SWsWpdyoc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}