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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '640b029152590d2dc3b001fd814a251505e97b33728d31d4276263f758158d4b' 
  AND token = '+9GpQK1je00Z3bkvnXX6cZ9mnuIsrsr8wrww2Tc3tSw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}