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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8b462a25ddd1e678451631bf95c36e147e7ebab3111d26d43a3035a9248f0cb' 
  AND token = 'TGp8W8M1r6dPPs7f2WY8XAuTgvzEAoVEVIxrC3LbZPA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}