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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2abc9cd1fdffa8d376bdf6b38441fd89eca44aa3a6837270f9e3aa8dc3aed725' 
  AND token = 'RN6QQRtd5edp78WZBQujPkC9qqI0uIO7TkjvOuXYvZg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}