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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78122b29ae38bb49b882faac4fe8423a12d16bf66f6caa1266a69ca45cf519ad' 
  AND token = 'vekxWDYv9U0eUVP/3/Rz/Is5H+SzyoZIbI3GMIoJDLM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}