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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49421b98bf232102de587eb35414db20aab0a42674f50f5fec1b41fb20361188' 
  AND token = 'KNY7CCYqqHgTWOcZrLID/k+M/G2hxXkEo7uNiBI1k2U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}