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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c280bf7132cdf472224d435b7e4822f11d21b48c4ae527fd8bb7e06f94c1415' 
  AND token = 'HUapyIF/OqWF28g51DK6IBE3kpBrEmCpn6Z8NWf3b64=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}