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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '722ab8b1e26ef3e9dd1c5541db5662fb49c2da9efa36c3c6962671bb6045865c' 
  AND token = 'zos9CjLmTun956mpdIsWtGSwXF4yrJvAwc0kDS1NITY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}