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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '849848f3c59225216af146341b449460b17201a2c081f165e2cf8e65143a74e6' 
  AND token = 'O1uEy+j4HTXh6/Z6k+OO9Yuiorm5/txt3uSOELsZw8E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}