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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01335655fa91e29f56f093de5f73f01628cf73a980d1120f96f7000e14c27a7e' 
  AND token = '1I0hW+Etjx3enaS7kNa+9+CsAERxvgIDMMmrVy53Ztg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}