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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ea7842bf42bd2121443fc3a6b6d33cde51517022a940cb0180d188f9f4121860' 
  AND token = 'iQ90ewuxMjF+EDKYCGgxoeOFM2QKbv3ZTQFH0s4HggM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}