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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '865cc36f4dcf81a289fd52657dc2bf230ddaba250dafc00c4a3f2d1f79165505' 
  AND token = 'kR0yRiDXiTP1kviF0PguAIjfDYnMy+KE2815AYqlXLY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}