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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c22a761b63d8f673e12a42bc2d1f02d74147877f8e221f5efe204d2c88ceb0c9' 
  AND token = 'JHwW4YRsoygRzOkqv/0Ejx4YF+UqMPPI+RRrLz1XL64=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}