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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ccc25ecc86e58ccea04d6d7bd172c4aeebdb2c28480663e8c84549ceced108d6' 
  AND token = 'R8IbkFYCoR8aWXlWSj9TUKOAKdQqAQAcKV3AmVzUIoI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}