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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '437f9dbe3302044676be79732542a7b4e6f94e9ccb961a6b9dd040843941a170' 
  AND token = 'lEwyp/HMQIqbbWOnjTxRS66ywGh5MOLhyQ/1hMD0RG0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}