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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e85eb8ab211de2179413e7c111eb0bb241ed5046e6adc23da4e76539f0a2391' 
  AND token = '9zId+NIT0d1G+O1tvoitkZKOFpRmK9b995xaZs3QRiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}