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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7434bcd9d927f8e09ac72091e76b8e43df3aee428f6a18db358544d3bd53a378' 
  AND token = 'DeJc1IRZ87sfa4ygtPmc+vwtEt2MAy+q5E++mL4E4F8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}