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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '79278b153bee1a9f5ccdec5322bc9613a65d8aeb1fcb9e77a666ea3f39271fc6' 
  AND token = 'x7Jl3sXihM5AKbLt6LVwkjHqtuazLr7X5wY/S5M2jjE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}