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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78297f212411a0701e39e89aaa041b20f9cb3d4fdfa93940d0a8d5f4f61f345a' 
  AND token = 'yemeLYhyKOmjWRpZ/tDauzuM8hgQ1cfTpenJppTz13I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}